![]() ![]() These best free books accelerate your learning of every programming language. There's a strict eligibility criteria for inclusion in this series. We showcase free Android apps that are definitely worth downloading. Getting Started with Docker helps you master Docker, a set of platform as a service products that delivers software in packages called containers.īest Free Android Apps. Have some fun and escape from the daily drudgery. Linux Candy reveals the lighter side of Linux. ![]() Linux at Home looks at a range of home activities where Linux can play its part, making the most of our time at home, keeping active and engaged. Now and Then examines how promising open source software fared over the years. Emulate home computers including the Commodore 64, Amiga, Atari ST, ZX81, Amstrad CPC, and ZX Spectrum. Home computers became commonplace in the 1980s. Small, indispensable tools, useful for anyone running a Linux machine. Linux utilities to maximise your productivity. Saving Money with Linux looks at how you can reduce your energy bills running Linux.Įssential Linux system tools focuses on small, indispensable utilities, useful for system administrators as well as regular users. Surveys popular streaming services from a Linux perspective: Amazon Music Unlimited, Myuzi, Spotify, Deezer, Tidal. Linux Around The World showcases events and usergroups that are relevant to Linux enthusiasts. Replace proprietary software with open source alternatives: Google, Microsoft, Apple, Adobe, IBM, Autodesk, Oracle, Atlassian, Corel, Cisco, Intuit, and SAS. We offer helpful and impartial information. Hundreds of in-depth reviews offering our unbiased and expert opinion on software. Each article is supplied with a legendary ratings chart helping you to make informed decisions. The largest compilation of the best free and open source software in the universe. We start right at the basics and teach you everything you need to know to get started with Linux. New to Linux? Read our Linux for Starters series. Learn C with our recommended free books and free tutorials. Support: Documentation, GitHub Code RepositoryįontForge is written in C. Internationalization support: (English), Russian, Japanese, French, Italian, Spanish, Vietnamese, Greek, Simplified & Traditional Chinese, German, Polish, and Ukrainian.Uses Potrace or AutoTrace to trace bitmap images and import them into a font.Convert fonts from one format to another, or can store fonts in its native text-based “spline font database” format (.sfd).Supports the unofficial Microsoft mathematical typesetting extensions (MATH table).Supports Adobe’s OpenType feature file specification.Supports many font formats, including TrueType, PostScript, OpenType, SVG, FON, FNT, Web Open Font Format, and TeX Bitmap fonts.Also included with FontForge are programs to generate a font thumbnail image, check for certain common errors and to compare two font files (fontimage, fontlint, and sfddiff respectively). ![]()
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![]() ![]() Red_Alert_2-Windows_8_and_10_Fix.zip will also contain these files in a folder called Compatibility Database: ![]() ![]() Stellar Phoenix Video Repair tool is an easy-to-use program to fix corrupted and damaged video files that are unplayable in QuickTime player on both Windows and macOS. It is extremely cost-effective.Ĭons: EaseUS data recovery software can only repair lost MP4, MOV, and GIF files recorded by cameras. Pros: EaseUS Data Recovery Wizard is a well-known program that integrates data recovery, picture, and video repair functions.
![]() They recorded an instrumental version of the classic song, " Carol of the Bells" for the X Christmas compilation album, which was featured in trailers for the film, The Spirit, released Christmas Day 2008. The band also visited Europe for a month-long headlining tour in November, playing in Germany, Finland, Norway, Sweden, The United Kingdom, Republic Of Ireland, Northern Ireland, Italy, Belgium, The Netherlands, Czech Republic, Slovakia, and France.Īfter this series of tours, the band recorded two covers of popular songs. In September and October of that same year, they headlined a tour with A Skylit Drive, Sky Eats Airplane, Greeley Estates, and This or the Apocalypse in the United States. From April to May they toured with As I Lay Dying and Misery Signals across the United States and Canada. Throughout 2008, August Burns Red toured with several acts across North America and Europe to promote Messengers. Marking the debut for Luhrs fronting the group, it became the band's breakthrough album, reaching number 81 on the Billboard 200. ![]() The band's second album, Messengers, was released on June 19, 2007. He was replaced by bassist Dustin Davidson, a friend of the band. Bassist Jordan Tuscan also left the band in 2006 for similar reasons as McManness. He was replaced by Jake Luhrs, then a resident of Montclair, New Jersey. McManness departed from the band in 2006, after only one tour. Vocalist Jake Luhrs joined the band in 2006 as the band's third and current lead vocalist In 2006, drummer Matt Greiner was endorsed by Truth Custom Drums following the release of the album. August Burns Red released Thrill Seeker, their first full-length album, on November 8, 2005. Hershey would later go on to form post-rock band Bells. After several months of playing with McManness, August Burns Red signed to Solid State Records in 2005. ![]() Vocalist Jon Hershey eventually quit the band during the same year, which led to Josh McManness taking on the position as lead singer. After playing many local shows within Lancaster, they recorded their first EP, titled Looks Fragile After All with label CI Records in 2004. ![]() The original practice sessions of the band began in drummer, Matt Greiner's old egg house and basement on the Greiner family's farmland. History Formation and Thrill Seeker (2003–2006) Īugust Burns Red was founded in March 2003 when all the members were attending high school. 1.8 Guardians and Death Below (2019–present). ![]() ![]() ![]() This clearly places marsupial meiosis at the heart of the discussion concerning sex chromosome evolution and the origin of gene dosage compensation in mammals. Similarly, recent characterisation of the mechanisms involved in the inactivation of sex chromosomes during marsupial meiosis has led to the idea that somatic inactivation of sex chromosomes in mammals may have originated from the more ancient and conserved mechanism of meiotic sex chromosome inactivation. Comparison of the meiotic mechanism present in marsupials with those present in some eutherian mammals opens new perspectives concerning the origin of sex chromosomes and sex chromosome segregation in the ancestor of marsupials and placental mammals. ![]() This structure maintains the association between the asynaptic and achiasmatic sex chromosomes during the first meiotic division, contributing to the proper segregation of sex chromosomes into daughter cells. The most relevant feature of marsupial male meiosis is the development of a synaptonemal complex-derived structure called the dense plate (DP). The highly differentiated X and Y chromosomes perform a precise and specific meiotic program that includes pairing and segregation, but lacks the usual mechanisms of synapsis, recombination and chiasma formation that occur in the autosomes and also in the sex chromosomes of eutherian mammals. While SAM's mechanism is NF-κB-dependent, MTA has both NF-κB-dependent and -independent mechanisms.The absence of homology between sex chromosomes in marsupials strongly influences their behaviour during male meiosis. In conclusion, SAM and MTA down-regulate BHMT expression in HepG2 cells in part by inducing NF-κB, which acts as a repressor for the human BHMT gene. Indeed, MTA treatment resulted in increased expression ER stress markers. MacVector is a comprehensive Macintosh application that provides sequence editing, primer design, internet database searching, protein analysis, sequence confirmation, multiple sequence alignment, phylogenetic reconstruction, coding region analysis, agarose gel simulation and a variety of other functions. Lower BHMT expression can impair homocysteine metabolism, which can induce ER (endoplasmic reticulum) stress. Protein Analysis Toolbox this is a collection of algorithms that generate profile plots displaying the likely hydrophobic, hydrophilic, antigenic and. The NF-κB binding site at −301 is responsible, at least in part, for this effect. MacVector is a comprehensive Macintosh sequence analysis application that provides sequence editing, primer design, internet database searching, protein analysis, sequence confirmation, multiple sequence alignment, phylogenetic reconstruction, coding region analysis, agarose gel simulation and a variety of other functions. Overexpression of p50 and p65 decreased BHMT promoter activity, while blocking NF-κB activation increased BHMT expression and promoter activity, and prevented SAM but not MTA's ability to inhibit BHMT expression. SAM and MTA treatment increased NF-κB nuclear binding and NF-κB-driven luciferase activities, and increased nuclear binding activity of multiple histone deacetylase co-repressors to the NF-κB sites. Maximal suppression was observed with the BHMT promoter construct −347/+33, which contains a number of NF-κB (nuclear factor κB) binding sites. Both SAM and MTA treatment of HepG2 cells resulted in a dose- and time-dependent decrease in BHMT mRNA levels, which paralleled their effects on the BHMT promoter activity. Finally, Swe1p degradation requires Hsl1p, a Nim1-family protein kinase. ![]() To facilitate these studies, we cloned the 2.7 kb 5′-flanking region of the human BHMT gene (GenBank® accession number AY325901). Met30p is an F-box protein that forms part of an SCF ubiquitin ligase. MacVector is a comprehensive Macintosh application that provides sequence editing, primer design, internet database searching, protein analysis, sequence confirmation, multiple sequence alignment, phylogenetic reconstruction, coding region analysis, and a wide variety of other functions. The present study examined regulation of the human BHMT gene by SAM and its metabolite, MTA (5′-methylthioadenosine). Transcriptional regulation of the human BHMT is also unknown. SAM ( S-adenosylmethionine) inhibits BHMT activity, but whether SAM modulates BHMT gene expression is unknown. Access content during the Covid-19 pandemicīHMT (betaine–homocysteine methyltransferase) remethylates homocysteine to form methionine. ![]() ![]() ![]() ![]() As a general rule of thumb, a change of 15° of longitude should result in a time difference of 1 hour. Many countries have more than one time zone. The following map displays the standard time zones across the world. As can be seen, although there is a general standard throughout the world for defining time zones, it is still highly dependent on the country, and is subject to change. Russia on the other hand, is divided into 11 time zones, though at one point this was reduced to 9 time zones. For example, China and India only use a single time zone even though they are countries that encompass far larger an area than 15° of longitude. Generally, a time change of 1 hour is required with each 15° change of longitude, but this does not necessarily always happen. It wasn't until 1929 before most countries adopted hourly time zones Nepal, the final holdout, did not adopt a standard offset of UTC until 1956, and even then, has a less common offset of UTC+5:45. Time zones throughout the world vary, and used to vary even more than they currently do. Most commonly, UTC is offset by an hour, but in some cases, the offset can be a half-hour or quarter-hour, such as in the case of UTC+06:30 and UTC+12:45. ![]() UTC offset can range from UTC-12:00 to UTC+14:00. Generally, time zones are defined as + or - an integer number of hours in relation to UTC for example, UTC-05:00, UTC+08:00, and so on. UTC breaks time into days, hours, minutes, and seconds, where days are usually defined in terms of the Gregorian calendar. Most time zones that are on land are offset from UTC. UTC is not dependent on daylight saving time (DST), though some countries switch between time zones during their DST period, such as the United Kingdom using British Summer Time in the summer months. UTC, which is based on highly precise atomic clocks and the Earth's rotation, is the new standard of today. Although GMT used to be a time standard, it is now mainly used as the time zone for certain countries in Africa and Western Europe. Although GMT and Coordinated Universal Time (UTC) essentially reflect the same time, GMT is a time zone, while UTC is a time standard that is used as a basis for civil time and time zones worldwide. Greenwich Mean Time (GMT) is the mean solar time at the Royal Observatory located in Greenwich, London, considered to be located at a longitude of zero degrees. They are often based on the boundaries of countries or lines of longitude. Related Time Calculator | Date CalculatorĪ time zone is a region on Earth that uses a uniform time. ![]() ![]() ![]() That equals a cost per gigabyte of 6 cents for the 1TB drive, 4 cents for the 2TB model, 2.8 cents for the 4TB unit, and 3 cents for 5TB. In addition to the 5TB version I tested, WD offers three other capacities for the Windows version of the drive, with list prices of $59.99 for 1TB, $79.99 for 2TB, and $119.99 for 4TB. Just be sure to back up any files on the drive first, so you can copy them back when you're done. You can, of course, reformat either version with the other file system to use the drive with the other OS, or reformat with exFAT if you want to move the drive freely between Windows systems and Macs. My Passport drives for Windows come formatted in the NTFS file system the Mac versions come with HFS+. ![]() ![]() (Opens in a new window) Read Our Western Digital My Book Review Pick up the drive, and it feels like a solid, well-built product. The partially rippled surface covers half of both the top and bottom, running from one corner to the diagonal center line on both, while an understated WD logo occupies the upper right corner of the top. Fit and finish are excellent, with no screws needed to hold the case together and no sharp edges to catch on clothing or a bag. The My Passport at least arguably earns WD's description of it as "stylish." The drive I have for testing, pictured here, is black, but you can also get versions formatted for Windows in a red or blue case, or one formatted for the Mac in a darker blue case only. Add a choice of colors, a size that can fit in a shirt pocket, a range of capacities from 1TB to 5TB (5TB is the top capacity you can get at the moment for a single-drive portable hard drive), and easy-to-find discounts from list price, and the WD My Passport is a clear standout and our new Editors' Choice among high-capacity portable hard drives. The ripples also help keep the drive from slipping out of your hand easily. Slightly rounded edges and ripples over part of the surface give the My Passport drive the look and tactile-friendly feel of a consumer gadget. One of the differences between a generic external hard drive and a top contender like the WD My Passport ($149.99 for the 5TB model tested here) is the manufacturer's added effort to make a simple plastic box look attractive. At list price, the 5TB version has a higher cost per gigabyte than the 4TB version.How to Set Up Two-Factor Authentication.How to Record the Screen on Your Windows PC or Mac.How to Convert YouTube Videos to MP3 Files.How to Save Money on Your Cell Phone Bill.How to Free Up Space on Your iPhone or iPad.How to Block Robotexts and Spam Messages. ![]() ![]() ![]() Britain was having a heatwave at the time, so the coconut oil was completely melted in the jar. First of all, I was horny (which always helps!) and began watching porn while I lubed the toy up with some coconut oil. Okay, so I’ve not exactly written a glowing review of this toy, but I should point out that it did still give me some pleasurable sensations and P-waves, so don’t write it off completely, especially if you’re a fan of stiffer prostate toys.ġ. Rather than gently press into your perineum and rub it delicately like the Helix Syn Trident, this toy seems to jab into your taint violently, with the plastic balls on the end of the arms leaving me with sores after a lengthy session. To slag these arms off further (sorry Aneros), they are way too stiff and pointed to be pleasurable. I tried this and found that it did help massively, though it meant that I couldn’t use the Maximus Trident in my favorite position (sat up, half leaning against my bedframe). It’s supposed to send chills up your spine or awaken your inner chakra or something, but it just gets in the way as far as I can tell.Īs one Aneros Reddit user pointed out, you need to place a pillow under your butt if using products with K-tabs on your back because otherwise they can disrupt the natural motion of the prostate massage. Of course, the perineum arm has obvious uses for external prostate stimulation, but this stupid “Kundalini tab” or “K-tab” that they keep pushing is ridiculous. With their new Trident series, Aneros seem hellbent on adding stupid stiff arms to their toys which are uncomfortable and don’t do a lot of good. To be honest, it’s not a feature that’s unique to the Maximus – I also equally hate the arms on the Progasm too. I’ve been using Aneros massagers for a while now, and I personally just find the rigidness to be uncomfortable inside me. Aneros claim that this is because “intermediate” prostate players should have developed the strength in their Kegel muscles to withstand this stiff design. On the flip side, my biggest complaint is how stiff and rigid this toy is compared to competing men’s anal toys. The material feels very durable and robust too, which is a plus if you like aggressive sessions. Although it’s not the sexiest material in the world, you can easily clean this toy with sex toy wipes alone if you wanted to, although warm soap and water is always recommended. The biggest upside with the construction of this toy is how easy it is to keep clean. However, this plastic non-porous coating on the Maximus Trident makes it very easy to slide in and slide out of your bottom, yet it somehow stays in place throughout your prostate play session. Unlike most of the new Aneros massagers in the Trident range, it doesn’t have the velvet-feel coating that makes some of their best prostate massagers so damn alluring. As far as I’m aware, this toy is 100% ABS plastic. ![]() ![]() ![]() ![]() Pay close attention: in the small environments the mirror is very important, because, if positioned in the correct way, it will help you make the room brighter and optically bigger.Īn important tone should also be applied to the choice of lighting : the mirror area must be illuminated impeccably, so as to facilitate daily actions such as make-up and shave therefore, if the installation of sconces or lamps is not foreseen, it is better to focus on mirrors with LED backlights or integrated lighting. Naturally, the size must be established on the basis of how many people will use it at the same time for example, if you prepare yourself in the morning with your partner or in any case with your family, you need to select a large product that you can use together.Īs far as the shape is concerned, let's move on from the more traditional, like the square and round, to more particular and elaborate figures. Naturally, the dimensions must be decided according to the proportions of the environment in which it will be inserted, in order to harmoniously match with the rest of the furnishings. The mirror is one of the most used accessories in our daily life, not by chance is placed in various rooms of our homes, in the living room, at the entrance, in the bedroom, but its maximum utility reaches it in the bathroom, where we make-up, we comb, shave and brush our teeth.Īs always before buying the mirror of our dreams we must take into consideration some main factors both from a practical and an aesthetic point of view:Ī mirror with the right dimensions and shapes will complete your furniture, making the bathroom even brighter. In the Mirrors category of our online shop we want to offer you a wide choice, proposing different models with different colors and perhaps, to help you decorate your bathroom according to your tastes, without sacrificing practicality, which distinguishes our products. In every bathroom an essential element, both from the practical point of view and from the aesthetic one, is the mirror, especially for a woman, in fact it is difficult to think of make-up, hair and shaving, correctly without using a mirror. ![]() ![]() ![]() ![]() The procedure to put the Pi function in an Excel spreadsheet is very simple. First, open the Microsoft Excel application from the start menu or by using the Windows search box. Then place the cursor in an empty cell. There, type =PI() and press ‘Enter’. Immediately, you will see the constant value that corresponds to Pi. What is the procedure to put the Pi function in my spreadsheet? It should be noted that no operations can be done with this value if the symbol π is inserted in Excel. However, you will be able to do any operation, be it adding, subtracting, multiplying or dividing the value of Pi with another element if you use the PI function. An element can be added directly or by using a cell reference. No operations can be done with this value The Pi function will always take the same constant value in Microsoft Excel. So no matter what formula you insert into your spreadsheet, the Pi function will take care of returning the corresponding mathematical constant. This value is widely used to perform equations, calculate areas of figures and apply certain particular functions. There are certain aspects that we must take into account before using the Pi function in Excel. First of all, such a function will always take the same constant value no matter what calculation is applied in the spreadsheet. In addition, it is important to note that we can do any type of operation with this value. What should we take into account before using the Pi function in Excel? What uses can we give to the Pi function in our Excel document?. ![]() What is the procedure to put the Pi function in my spreadsheet?.No operations can be done with this value.What should we take into account before using the Pi function in Excel?.If you do not want your writing to be edited mercilessly and redistributed at will, then do not submit it here.Excel is one of the most useful applications in the field of office automation. This tool allows you to use formulas and functions to obtain calculations quickly. Because of this, you may want to know how to use the Pi function in a Microsoft Excel document. In this regard, in this tutorial we show you the best tips and uses of this program . Use thereof is explained in our trademark policy (see Project:Copyrights for details). Their respective logos and icons are also subject to international copyright laws. "LibreOffice" and "The Document Foundation" are registered trademarks of their corresponding registered owners or are in actual use as trademarks in one or more countries. This does not include the source code of LibreOffice, which is licensed under the GNU Lesser General Public License ( LGPLv3). Please note that all contributions to The Document Foundation Wiki are considered to be released under the Creative Commons Attribution-ShareAlike 3.0 Unported License, unless otherwise specified.Based on work by Steve Fanning, The Document Foundation Wiki user Gilward Kukel and others. This page was last edited 17:41:46, by Ilmari Lauhakangas.Section 6.16.45, part 2 Equivalent Excel functions: The area of a circle is given by \displaystyle. Here the formula calculates the area in cm 2 of a circle of radius 4 cm. Here the function returns the value of π to 14 decimal places. For more background information about π, visit Wikipedia's Pi page.Multiply the degrees by π/180 (approximately 0.01745329252) to convert to radians.Multiply the radians by 180/π (approximately 57.295779513) to convert to degrees.A common use of π is in converting angles between radians and degrees.π can be defined as the ratio of a circle's circumference to its diameter.The real number 3.14159265358979, which is the approximate value of π to 14 decimal places. Returns the approximate value of the mathematical constant π to 14 decimal places. ![]() |
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